News & Research

arXiv:2606.01051v1 Announce Type: new Abstract: Dynamic medical treatment requires deciding treatment intensity and intervention timing, while patient states evolve continuously and adverse events may occur between clinical interactions. Most existing treatment learning methods assume fixed schedules or enforce safety only at discrete decision points. We propose Interaction-Limited Safe Continuous-Time Reinforcement Learning, a framework that jointly optimizes treatment administration and clinical interaction timing under trajectory-level safety constraints. Our key idea is to reformulate the continuous time treatment problem as an option-based semi-Markov decision process, where each option specifies a continuous-time treatment policy and its duration. We develop a safety-tightening mechanism showing that suitably constructed constraints at interaction times guarantee safety over the full continuous-time trajectory with high probability. We further establish finite-sample guarantees f

arXiv:2606.00555v1 Announce Type: new Abstract: Structure-based drug design increasingly employs LLM agents to iteratively refine ligands against a target pocket, yet a viable ligand must satisfy two often-conflicting objectives -- binding affinity and druggability -- which single optimization steps rarely improve together. To quantify this difficulty, we introduce two diagnostic metrics: the first measures how often a single edit improves both objectives, and the second measures how often a gain on one objective comes with a loss on the other. Applying these diagnostics to current LLM-agent pipelines exposes a consistent failure mode: the agent performs molecular editing without knowing how the pocket-ligand complex responds to local modifications, thus rarely achieving joint improvement. Inspired by medicinal chemists, who probe the pocket-ligand complex with controlled analog edits before choosing an optimization direction, we propose \textbf{PROBE}, an optimization framework built

arXiv:2606.00011v1 Announce Type: cross Abstract: Despite the promise of AI to assist complex decisions, practitioners still lack ways to detect likely failures and inspect the consequences of model edits before committing them. We present RuleEdit, an interactive, rule-guided human-AI model editing system that (i) surfaces likely failures through interpretable mismatch signals from rule tables and (ii) supports user-authored rule feedback with prospective previews of projected performance changes and embedding shifts. We instantiate RuleEdit in stroke rehabilitation assessment and evaluate it with health professionals and students. Rule-guided failure detection significantly increased Human + AI performance by 14.16\% ($p<0.001$) while improving rejection of incorrect AI and reducing both over- and under- reliance as well as ChangedToWrong decisions. In addition, presenting prospective embedding previews improved participants' feedback for model adaptation, increasing post-update loca

arXiv:2606.02219v1 Announce Type: new Abstract: Object pose estimation is a fundamental problem for an agent system to perceive or manipulate objects in images or videos. However, current instance-level methods struggle with generalization to unseen objects. Category-level methods seek to address this, but remain constrained by the complexities of learning in the non-linear Sim(3) space and intra-class variations. To address these challenges, We propose an effective method for category-level object pose estimation with two key innovations: (1) A translation/size estimator, featuring a semantic-guided symmetry-aware module that leverages robust generalization capabilities of a large vision model (LVM) to infer symmetry points, resulting in accurate translation and size without shape priors. This result serves as a precomputed cue for rotation estimation, thereby reducing the difficulty of learning in the non-linear Sim(3) space and laying a robust foundation for tackling the inherently

arXiv:2606.00782v1 Announce Type: new Abstract: Open-vocabulary object detection (OVD) has achieved remarkable progress through large-scale vision-language pre-training. Existing methods, however, typically formulate OVD as a discriminative prediction problem, where decoder queries are either static or initialized from encoder features, thus limiting their diversity and flexibility. In this paper, we introduce a generative perspective by modeling decoder query generation as a continuous transport process in latent space. We propose FlowOVD, a text-conditioned query generation framework based on rectified flow that progressively transforms text-agnostic queries into text-guided queries. By introducing continuous latent query dynamics into a vision-language model (VLM) based detector, our method avoids heuristic discrete query construction and enables more expressive semantic alignment for open-vocabulary detection. Without requiring additional training data, FlowOVD achieves 49.5 AP on

arXiv:2606.02544v1 Announce Type: cross Abstract: Diffusion large language models (dLLMs) have recently emerged as a promising alternative to autoregressive (AR) LLMs, offering faster inference through parallel or blockwise decoding. However, their masked language modeling formulation remains incompatible with standard token-level speculative decoding, one of the most effective acceleration techniques for AR models. In AR decoding, the causal mask preserves temporally valid token-level contexts, enabling a target model to verify multiple drafted tokens in a single forward pass. In contrast, dLLMs rely on mask tokens and bidirectional attention, causing the effective context to change across denoising steps and preventing direct token-level speculative verification. To bridge this gap, we propose a simple but effective speculative decoding algorithm for diffusion language models, named SimSD, which mainly adopts a plug-and-play masking strategy that equips dLLMs with temporally valid to

arXiv:2606.01334v1 Announce Type: new Abstract: Open-set 3D recognition requires models that generalize to rare or unseen categories. Recent approaches address this by distilling language-vision knowledge into 3D encoders, typically relying on heavy 2D ViTs and aligning each point cloud with a single image or caption, thus anchoring representations to partial views. We propose aligning each point cloud with multiple images and textual descriptions to capture a more holistic understanding of 3D objects. To realize this idea, it is essential to design a loss function capable of jointly aligning a 3D instance with multiple matched signals, multi-view images and multiple texts, while separating positive aggregation from negative competition. We introduce such a function, termed the decoupled multi-positive contrastive loss. Our formulation enhances the loss's hardness-aware focus on challenging negatives, avoiding the "spotlight crowding" that occurs when many positives share the same soft

arXiv:2511.04873v2 Announce Type: replace-cross Abstract: Prototype selection methods compress a training set, but the existing taxonomy of condensation, edition, hybrid, competence-based, optimization-based, and clustering-based families does not include methods that operate on the multi-scale topological structure of the data. This paper introduces two different persistence-based prototype selector variants, Topological Prototype Selector (TPS) and Boundary-Conscious Topological Prototype Selector (BoundaryTPS). TPS uses two sequential Rips filtrations to retain boundary-relevant and interior-typical points. BoundaryTPS is a single-stage variant whose vertex-weighted filtration concentrates retention near the decision boundary. We evaluate both methods against seven classical baselines on fifteen real datasets and find that the topological methods occupy a different operating point in the prototype-selection design space than existing methods. BoundaryTPS achieves the lowest mean Fri

arXiv:2606.00462v1 Announce Type: cross Abstract: Short-form text rewriting is a constrained variant of paraphrasing in which limited context and high semantic density leave little room for variation. While large language models perform well on general paraphrasing, small language models (SLMs) often struggle with semantic fidelity and hallucination robustness in short-form settings. In this work, we present an empirical study of adapting an SLM, Phi Silica, for short-form rewrite through dataset curation, prompt distillation, parameter-efficient fine-tuning, and evaluation. We curate a dataset of short presentation-style text from public slide decks and use GPT-5-chat both to generate rewrite supervision and to conduct LLM-as-a-judge evaluation. Our results show that finetuning improves semantic fidelity, reduces hallucinations, and increases preference win rate against GPT-5-chat rewrites. The findings suggest that targeted adaptation for SLMs can substantially narrow the gap to clou

arXiv:2606.02044v1 Announce Type: new Abstract: Diffusion MRI enables non-invasive probing of tissue microstructure, but accurate parameter estimation is challenged by noise-related effects. In supervised machine learning frameworks trained on simulated data, discrepancies between the noise characteristics of simulated and acquired signals introduce a form of covariate shift, whereby the input signal distribution differs between training and inference. We investigated the impact of this mismatch on microstructure parameter estimation and propose a realistic noise synthesis (RNS) framework to mitigate it. RNS incorporates both the Rician expectation and the effective post-processing noise variance into simulated training signals. The Rician expectation was modelled using a noise standard deviation estimated with MPPCA, while the effective standard deviation was derived from spherical harmonic residuals of preprocessed data. The method was evaluated using the cylinder-zeppelin and the SA

arXiv:2602.11177v2 Announce Type: replace-cross Abstract: Reliable early detection of Alzheimer's disease (AD) is challenging, particularly due to the limited availability of labeled data. While large language models (LLMs) have shown strong transfer capabilities across do mains, adapting them to the AD domain through supervised fine-tuning remains largely unexplored. In this work, we empirically evaluate various model architectures across three heterogeneous transcript corpora (Pitt, CCC, ADRC) to investigate their effectiveness for text-based AD detection and analyze how task-relevant information is encoded within their internal representations. To the best of our knowledge, our fine-tuned BERT and T5 models establish a new state-of-the-art on the Pitt and CCC datasets, while achieving strong performance on ADRC. In parallel, the decoder-only Llama-1B achieves highly competitive results comparable to BERT and T5 across all three corpora, highlighting its effectiveness for AD detectio

arXiv:2509.05367v5 Announce Type: replace-cross Abstract: Large Language Model safety alignment predominantly operates on a binary assumption that requests are either safe or unsafe. This classification proves insufficient when models encounter ethical dilemmas, where the capacity to reason through moral trade-offs creates a distinct attack surface. We formalize this vulnerability through TRIAL, a multi-turn red-teaming methodology that embeds harmful requests within ethical framings. TRIAL achieves high attack success rates across most tested models by systematically exploiting the model's ethical reasoning capabilities to frame harmful actions as morally necessary compromises. Building on these insights, we introduce ERR (Ethical Reasoning Robustness), a defense framework that distinguishes between instrumental responses that enable harmful outcomes and explanatory responses that analyze ethical frameworks without endorsing harmful acts. ERR employs a Layer-Stratified Harm-Gated LoRA