News & Research

arXiv:2605.27413v1 Announce Type: cross Abstract: Proteins perform their biological functions through three-dimensional structures encoded by amino acid sequences, and ligand-binding protein co-design requires models that generate sequence-structure compatible proteins under explicit ligand constraints. Although continuous diffusion and flow-based models support ligand-aware design in coordinate or latent spaces, existing discrete diffusion protein language models mainly operate over sequence or structure tokens without direct small-molecule conditioning. We introduce \textbf{ProtLiD$^2$}, a \textbf{Prot}ein \textbf{L}igand-conditioned \textbf{D}iscrete \textbf{D}iffusion model for protein sequence-structure co-design. ProtLiD$^2$ jointly generates amino-acid sequence and discrete structure tokens while incorporating ligand chemical and geometric information through geometry-aware cross-attention. Trained on over one million ligand-protein complexes, ProtLiD$^2$ extends masked discrete

arXiv:2605.21832v2 Announce Type: replace Abstract: Modern recommender systems rely heavily on ID-based collaborative filtering: each item is represented by a unique ID embedding that accumulates collaborative signals from user interactions. Livestreaming recommendation, however, faces a unique challenge in this paradigm: a live room typically broadcasts for only tens of minutes, so its item ID remains poorly learned in a persistent cold-start state and ID-centric ranking models fail to generalize. We present FLUID, the first framework to fully retire the candidate-side item ID from a production-scale livestreaming ranker. FLUID introduces a cross-domain multimodal encoder, jointly trained on short videos and livestreams, to produce discrete hierarchical semantic codes, called LUCID, for content-based item characterization. To adapt the ranker to LUCID, FLUID further employs a staged warmup scheme: it first incorporates cold, slice-level LUCID as an independent token alongside the ID e

arXiv:2605.28142v1 Announce Type: new Abstract: Inference-time sampling can elicit strong reasoning abilities from language models without additional training. Existing power-sampling methods do so by sharpening the distribution over full generated outputs, favoring completions that are individually likely under the model. We argue that this is the wrong object to target for reasoning: a completion entangles a reasoning trace with a final answer, whereas what matters is whether an answer is supported by many plausible reasoning paths. We therefore shift the target from the full-output distribution to the sharpened answer marginal, making self-consistency an inference-time objective rather than a post-hoc voting criterion. Surprisingly, this marginal target admits an efficient approximation: we propose a simple, purely autoregressive parallel sampling algorithm that approximately samples from the sharpened answer marginal, eliciting stronger performance than standard power sampling on m

arXiv:2605.27394v1 Announce Type: cross Abstract: Determining whether published scientific findings can successfully be replicated is a long-standing challenge in the empirical sciences. Existing approaches for replicability assessment typically rely either on human judgment, i.e., creative assembly of human experts, or on machine learning models trained on paper content metadata. While both approaches have demonstrated value, each also has important limitations. Human forecasts can be influenced by cognitive biases and narrow exposure to the research literature, while automated assessments often struggle to capture contextual cues and subtle signals of credibility. In this paper, we examine a hybrid approach. Specifically, we introduce a hybrid prediction market in which algorithmic agents trade alongside human participants to jointly estimate the likelihood that a published scientific finding will be corroborated via the outcome of a controlled replication study. Agents are trained o

arXiv:2605.12929v2 Announce Type: replace-cross Abstract: Retinal diagnosis is inherently bilateral: clinicians compare homologous structures across eyes (e.g., optic disc asymmetry), yet most deep models operate on monocular representations. We investigate whether explicit structural correspondence improves diagnosis, and propose Anatomy-Slot to operationalize this hypothesis. Anatomy-Slot introduces an unsupervised anatomical bottleneck by decomposing patch tokens into a set of emergent, structurally-coherent slots that correspond to anatomical regions, then aligning these slots across eyes via bidirectional cross-attention. On ODIR-5K with $n=10$ seeds, the method improves AUC by $4.2$ points over a matched ViT-L baseline (95% CIs; Wilcoxon signed-rank test, $W=0$, $p=0.002$). Pairing disruption and stress testing under Gaussian noise provide controlled tests of correspondence dependence and robustness under corruption. We further report quantitative optic disc grounding on REFUGE a

arXiv:2510.08555v2 Announce Type: replace Abstract: Existing controllable video generation methods are typically designed for rigid, task-specific settings, such as first-frame image-to-video, inpainting, or interpolation, treating spatio-temporal control as a set of isolated problems. We formalize a unified task, arbitrary spatio-temporal video completion, where a model generates a coherent video from user-specified patches placed at any spatial location and timestamp. However, realizing such a unified framework within modern latent video diffusion models is non-trivial: causal video VAEs compress multiple frames into a single latent slot, making frame-level conditioning fundamentally ill-posed, and directly feeding sparsely populated, zero-padded video inputs into the VAE leads to severe out-of-distribution artifacts. To address these challenges, we propose VideoCanvas, a simple yet effective framework that adapts the In-Context Conditioning paradigm to arbitrary spatio-temporal comp

arXiv:2605.27580v1 Announce Type: new Abstract: A central puzzle for the behavioural sciences and for human-facing artificial intelligence is the persistence of within-person variability. The same individual, presented with the same observable input, produces different outcomes on different occasions, and different individuals produce divergent outcomes that no observable covariate fully predicts. We argue that this variability belongs in the dynamic latent state of the person, and that human outcomes are controllable in a precise and operational sense through interventions that target the state and its weighting at the moment a decision is being formed. We define a state as the time-indexed weighting vector over the dimensions that govern how an individual's biology, physiology, and neuropsychology process the next event into a decision and an outcome. The relationship between state, decision, and outcome is causal rather than correlational. The weighting vector is dynamic at sub-dail

arXiv:2605.27616v1 Announce Type: cross Abstract: Real-time anomaly segmentation demands both high recall and efficient low-precision inference. We study the three-way interaction of model architecture, model scale, and FP4 quantization-aware training (QAT) recipe on a recall-critical brain tumor segmentation task, evaluating multiple architectures, scales, and QAT recipes under a unified protocol. We find that architecture choice has the largest impact on quantization robustness, with attention-based architectures showing remarkable resilience to recipe choice while CNN degrades under gradient-quantizing recipes at larger scales. At low capacity, FP4 can discretize softmax attention, but advanced QAT recipes prevent this collapse. At larger scales, advanced recipes mitigate gradient quantization noise that degrades CNN quality. Five-fold patient-level cross-validation confirms these findings are robust to data partition. Our results show that the Swin Transformer is robust to QAT reci

arXiv:2605.27906v1 Announce Type: new Abstract: Multimodal Large Reasoning Models introduce the reasoning paradigm, demonstrating strong capabilities on complex vision-language tasks. However, they still suffer from severe hallucinations. Existing training-based methods typically mitigate hallucinations through response-level direct preference optimization (DPO), where the Chain-of-Thought (CoT) and the final answer are treated as a monolithic output and optimized jointly. We reveal that this formulation performs similarly to answer-only optimization, suggesting that it primarily learns answer-level preference, while leaving CoT-level supervision insufficiently exploited. To address this issue, we explicitly formulate a CoT-oriented preference term and derive Reasoning-Conditioned Direct Preference Optimization (RC-DPO), which models the CoT as a condition for answer generation and contrasts the preference for the same preferred answer under different CoT conditions, promoting answer-s

arXiv:2605.28032v1 Announce Type: new Abstract: Large Language Models are increasingly applied in the petroleum industry, highlighting the need for a domain-specific evaluation framework. This study develops a benchmark for LLMs in petroleum engineering, including a three-stage process of data preprocessing, quality filtering, and multi-model validation. Using expert review, a standardized question bank with strong domain relevance and discriminative capability was constructed. The benchmark covers production, reservoir, and drilling engineering, with 1,200 questions across multiple-choice, true or false, term definition, and short-answer formats. Eight mainstream LLMs were evaluated under a unified API environment. Results show that models performed better on subjective than objective questions, indicating weaknesses in factual knowledge discrimination. The highest accuracies for multiple-choice and true or false questions were 65.3% and 74.3%, respectively. Gemini-3-Pro, Kimi-K2.5, a

arXiv:2605.28028v1 Announce Type: new Abstract: Group Relative Policy Optimization (GRPO) is widely used for training reasoning models, but updating all sampled completions in each group incurs substantial cost and can reinforce verbose reasoning trajectories. In this paper, we study whether all completions provide equally useful update signals in GRPO-style reasoning RL. Our gradient-similarity analysis shows that, within the same prompt group, same-class completions often induce highly similar update directions, whereas correct-incorrect pairs provide more distinct contrastive signals. Motivated by this observation, we propose Binary Prefix Policy Optimization (BPPO), which uses the shortest correct completion and the shortest incorrect completion as a compact update unit while preserving full-group advantage normalization. BPPO further improves efficiency with adaptive completion scheduling and prefix-focused optimization; by updating only response prefixes, it avoids reinforcing re

arXiv:2605.27561v1 Announce Type: cross Abstract: Introduction. Early detection of malignant skin lesions is critical for prognosis, yet dermatologist shortages in Russian regions limit screening coverage. Mobile dermoscopy clinical decision support systems (CDSS) offer a promising approach, with model interpretability and standardised patient routing remaining key barriers to adoption. Aim. To develop a quantitative interpretability assessment method for cascade deep learning models and a three-zone patient routing algorithm, and to conduct a preliminary single-centre prospective clinical validation of the Melanoscope AI CDSS in Russian outpatient practice. Material and methods. Two-stage cascade classification of dermoscopic images; attention map visualisation (attention rollout for ViT and Swin; Grad-CAM for ConvNeXt and EfficientNetV2); quantitative IoU-based agreement assessment between activation maps and expert annotations; prospective single-centre validation across four "Melan

arXiv:2503.01829v4 Announce Type: replace-cross Abstract: Large Language Models (LLMs) demonstrate persuasive capabilities that rival human-level persuasion. While these capabilities can be used for social good, they also present risks of potential misuse. Beyond the concern of how LLMs persuade others, their own susceptibility to persuasion poses a critical alignment challenge, raising questions about robustness, safety, and adherence to ethical principles. To study these dynamics, we introduce Persuade Me If You Can (PMIYC), an automated framework for evaluating persuasiveness and susceptibility to persuasion in multi-agent interactions. Our framework offers a scalable alternative to the costly and time-intensive human annotation process typically used to study persuasion in LLMs. PMIYC automatically conducts multi-turn conversations between Persuader and Persuadee agents, measuring both the effectiveness of and susceptibility to persuasion. Our comprehensive evaluation spans a diver

arXiv:2510.03534v5 Announce Type: replace-cross Abstract: We study the problem of long-term (multiple days) mapping of a river plume using multiple autonomous underwater vehicles (AUVs), focusing on the Douro river representative use-case. We propose an energy - and communication - efficient multi-agent reinforcement learning approach in which a central coordinator intermittently communicates with the AUVs, collecting measurements and issuing commands. Our approach integrates spatiotemporal Gaussian process regression (GPR) with a multi-head Q-network controller that regulates direction and speed for each AUV. Simulations using the Delft3D ocean model demonstrate that our method consistently outperforms both single- and multi-agent benchmarks, with scaling the number of agents both improving mean squared error (MSE) and operational endurance. In some instances, our algorithm demonstrates that doubling the number of AUVs can more than double endurance while maintaining or improving accu

arXiv:2605.03517v3 Announce Type: replace Abstract: Self-supervised learning (SSL) excels at finding general-purpose latent representations from complex data, yet lacks a unifying theoretical framework that explains the diverse existing methods and guides the design of new ones. We cast SSL as latent distribution matching (LDM): learning representations that maximize their log-probability under an assumed latent model (alignment), while maximizing latent entropy to prevent collapse (uniformity). This view unifies independent component analysis with contrastive, non-contrastive, and predictive SSL methods, including stop gradient approaches. Leveraging LDM, we derive a nonlinear, sampling-free Bayesian filtering model with a Kalman-based predictor for high-dimensional timeseries. We further prove that predictive LDM yields identifiable latent representations under mild assumptions, even with nonlinear predictors. Overall, LDM clarifies the assumptions behind established SSL methods and